SpOtOn’s reagents and services are the end-result of many years of clinical research by Professor Dalton and Mr Turner. Their work has covered many different areas over and above those directly related to the products currently offered by SpOtOn. Selected publications are presented below.
Renal Function and Nephrotoxicity
Dalton, R. N., M. J. Wiseman, et al. (1988). “Measurement of urinary para-aminohippuric acid in glycosuric diabetics.” Kidney International 34(1): 117-120.
Schultz, C. J., R. N. Dalton, et al. (2000). “Freezing method affects the concentration and variability of urine proteins and the interpretation of data on microalbuminuria. The Oxford Regional Prospective Study Group.” Diabetic Medicine 17(1): 7-14.
Lawson, N., T. Lang, et al. (2002). “Creatinine assays: time for action?” Annals of Clinical Biochemistry 39(Pt 6): 599-602
Amin, R., C. Turner, et al. (2005). “The relationship between microalbuminuria and glomerular filtration rate in young type 1 diabetic subjects: The Oxford Regional Prospective Study.” Kidney International 68(4): 1740-1749.
Dunger DB, Schwarze CP, Cooper JD, Widmer B, Neil HAW, Shield J, Edge JA, Jones TW, Daneman D, Dalton RN. (2007) Should we be identifying adolescents at high risk for nephropathy before the development of microalbuminuria? Diabetic Medicine, 24, 131-136
Preiss, D. J., I. M. Godber, et al. (2007). “The influence of a cooked-meat meal on estimated glomerular filtration rate.” Annals of Clinical Biochemistry 44(Pt 1): 35-42.
Ansquer JC, Dalton RN, Causse E, Crimet D, Le Malicot K, Foucher C (2008) Effect of fenofibrate on kidney function: a 6-week randomized crossover trial in healthy people. American Journal of Kidney Diseases, 51, 904-913
Dalton, R. N. (2010). “Serum Creatinine and Glomerular Filtration Rate: Perception and Reality.” Clinical Chemistry 56(5): 687-689.
\Marcovecchio, M. L., et al. (2010). “Symmetric dimethylarginine, an endogenous marker of glomerular filtration rate, and the risk for microalbuminuria in young people with type 1 diabetes.” Archives of Disease in Childhood 95(2): 119-124.
Dalton, R. N. and C. Turner (2010). “Development of a reference MS/MS method for plasma creatinine.” Clinica Chimica Acta 411(11-12): 904-905.
Lamb, E., et al. (2014). “The eGFR-C study: accuracy of glomerular filtration rate (GFR) estimation using creatinine and cystatin C and albuminuria for monitoring disease progression in patients with stage 3 chronic kidney disease – prospective longitudinal study in a multiethnic population.” BMC Nephrology 15(1): 13.
Looker, H. C., et al. (2015). “Biomarkers of rapid chronic kidney disease progression in type 2 diabetes.” Kidney Int 88(4): 888-896.
Dixon, J. J., et al. (2015). “Validation of a continuous infusion of low dose Iohexol to measure glomerular filtration rate: randomised clinical trial.” J Transl Med 13: 58.
Rowe, C., et al. (2019). “Biological variation of measured and estimated glomerular filtration rate in patients with chronic kidney disease.” Kidney International 96(2): 429-435.
Inusa, B. P. D., et al. (2021). “Reliability of different estimated glomerular filtration rate as measures of renal function in children with sickle cell disease.” Blood Cells, Molecules, and Diseases 91: 102590.
Ostermann, M., et al. (2020). “Micronutrients in critically ill patients with severe acute kidney injury – a prospective study.” Sci Rep 10(1): 1505.
Metabolic disease, nutrition and more.
Collins JE, Nicholson NS, Dalton N, Leonard JV (1994) Biotinidase deficiency: early neurological presentation. Dev Med Child Neurol, 36, 268-270.
Rahman, S., et al. (1997). “Late presentation of biotinidase deficiency with acute visual loss and gait disturbance.” Developmental Medicine & Child Neurology 39(12): 830-831.
Steinberg SJ, Fensom AH, Dalton NR, Toseland PA, Kennedy CR, Mowat AP (1994) Measurement of plasma very long-chain fatty acids as a preliminary screening procedure for the diagnosis of peroxisomal disorders. J Inherited Metab Dis, 17, 323-326.
Alagratnam, D., A. S. Wierzbicki, et al. (2000). “Serum homocysteine, folate and thermolabile variant of MTHFR in healthy Sri Lankans living in London.” Atherosclerosis 149(1): 221-222.
Dalton RN (2002) Appropriate metabolic investigations for the autistic child. BIMDG Bulletin, 22, 28-29.
Wraige, E., M. P. Champion, et al. (2002). “Fat oxidation defect presenting with overwhelming ketonuria.” Archives of Disease in Childhood 87(5): 428-429.
Dalton RN and Turner. C (2005). “Leucocyte cystine: The Key Measurement.” Journal of Inherited Metabolic Disease 28: 1206-1207.
Aledo R, Mir C, Dalton RN, Turner C, Pie J, Hegardt FG, Casals N, Champion MP (2006) Refining the diagnosis of mitochondrial HMG-CoA synthase deficiency. Journal of Inherited Metabolic Disease, 29, 207-211.
Khalid, J. M., J. Oerton, et al. (2010). “Relationship of Octanoylcarnitine Concentrations to Age at Sampling in Unaffected Newborns Screened for Medium-Chain Acyl-CoA Dehydrogenase Deficiency.” Clinical Chemistry 56(6): 1015-1021.
Turner, C., et al. (2013). “Effect of a 300 000-IU loading dose of ergocalciferol (Vitamin D2) on circulating 1,25(OH)2-vitamin D and fibroblast growth factor-23 (FGF-23) in vitamin D insufficiency.” Journal of Clinical Endocrinology & Metabolism 98(2): 550-556.
Prentice, P., et al. (2013). “Stability of metabolites in dried blood spots stored at different temperatures over a 2-year period.” Bioanalysis 5(12): 1507-1514.
Sternberg, J. M., et al. (2017). “Kynurenine Pathway Activation in Human African Trypanosomiasis.” J Infect Dis 215(5): 806-812.
Laeremans, H., et al. (2020). “Inter-laboratory analytical improvement of succinylacetone and nitisinone quantification from dried blood spot samples.” JIMD Reports 53(1): 90-102.
Yeo, M., et al. (2020). “Clinical utilization of dried blood spot nitisinone (NTBC) and succinylacetone (SA) concentrations in hereditary tyrosinaemia type 1 – A UK centre experience.” Annals of Clinical Biochemistry 57(6): 412-419
Halligan, R. K., et al. (2022). “Understanding the role of SGLT2 inhibitors in glycogen storage disease type Ib: the experience of one UK centre.” Orphanet Journal of Rare Diseases 17(1): 195.
Valo, E., et al. (2022) Effect of serum sample storage temperature on metabolomic and proteomic biomarkers. Scientific Reports 12, 4571 DOI: 10.1038/s41598-022-08429-0
Schwahn, B. C., et al. (2024). “cPMP rescue of a neonate with severe molybdenum cofactor deficiency after serendipitous early diagnosis and characterisation of a novel MOCS1 variant.” Molecular Genetics and Metabolism: 108598.